SZAFRAN®

Naturally Grow Back

Your Memory Connections.

Naturally Grow Back

Your Memory Connections.

Bacopin® obtained from the leaves of Bacopa monniera (Bacopa monnieri) is commonly known as a natural memory enhancing herb.

Sabinsa offers two different grades of Bacopa extract standardized for minimum of :

· 20% Bacosides

· 50% Bacosides

The major constituents (actives) of Bacopa are Bacosides which was found to supplement cognitive function.

Chemical structure of some saponins isolated from Bacopa

monniera. Phytomedicine 12 (2005) 305-317

Traditional Knowledge

B. monniera, known colloquially as ‘Brahmi’ has been used traditionally as a brain tonic to enhance memory development, learning, concentration and to alleviate symptoms associated with anxiety and epileptic disorders. The name ‘Brahmi’ is derived from the word ‘Brahma’ which translates to ‘mythical creator’ in Hindu mythology. According to Indian philosophy, the brain is considered to be the center of creative activity, thereby rightly naming a nutrient that improves this ability as ‘Brahm’.

Mechanism of Action

Repairing damaged neurons: Bacosides are reported to promote nerve impulse transmission by repairing damaged neurons. This is done by enhancing kinase activity, neuronal synthesis and restoration of synaptic activity. (Singh HK et. al (1997). Indian J. Pharmacol., 29:5359-365)

Inhibiting Acetylcholinesterase (AChE): Acetylcholinesterase hydrolyzes the neurotansmitter Acetycholine. It is found at neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. Higher levels of AChE have been reported to play a major role in the progression of Alzheimer’s disease.

B. monniera suppresses the function of AChE in the cerebral cortex, particularly in the parietal cortex and hippocampus, leading to increased availability of Acetylcholine. This facilitates enhanced attention, memory and cognitive processing thereby resulting in enhanced working memory.

Preclinical study

The oral dose (100 mg/kg body weight) of B. monniera extract inhibited acetylcholinesterase differentially in various parts of the animal brain viz. Cerebral cortex (51.6%) > Cerebellum (51%) > Pons (44%) > Thalamus (41.6%) > Hippocampus (38.1%) > Brain stem (34.3%) > Striatum (24.9%).

Clinical studies

In a randomized double-blind placebo-controlled study, 60 healthy elderly volunteers (mean age 62) consisting of 23 males and 37 females, received either a standardized extract of B. monniera (300 and 600 mg) or placebo daily for 12 weeks.

B. monniera at a dose of 300mg/day was found to

- Improve memory power

- Improve speed & continuity of attention

- Improve memory quality

- Decrease age related negative deflection (N100) and positive deflection (P300) latencies.

=P <0.05, *=P < 0.01, *** = P < 0.001 when compared to placebo-treated group.

B. monniera extract (300mg/kg) suppresses AChE activity resulting in enhanced cholinergic function, which in turn enhances attention and memory processing and gives rise to increased working memory.

These results suggest that B. monniera can improve attention, cognitive processing, and working memory partly via the suppression of AChE activity.

Nutraceutical Applications:

✔ Supports Normal Memory Function and Reduces Absent mindedness*

✔ Improves Mild Memory Problems Associated With Aging*

✔ Promotes Brain Function And Mental Clarity*

✔ Reduces Stress-Related Anxiety *

✔ Improves Memory, Focus And Recall In Healthy People*

Dosage form and Suggested use level:

Bacopin® can be used in the form of capsules or tablets.

Suggested use level of Bacopin® 50%

Adult : 50 mg of extract 3 times daily.

Children : 25 mg of extract 3 times daily.

SZAFRAN®

Bacopin® obtained from the leaves of Bacopa monniera (Bacopa monnieri) is commonly known as a natural memory enhancing herb.

Sabinsa offers two different grades of Bacopa extract standardized for minimum of :

· 20% Bacosides

· 50% Bacosides

The major constituents (actives) of Bacopa are Bacosides which was found to supplement cognitive function.

Chemical structure of some saponins isolated from Bacopa

monniera. Phytomedicine 12 (2005) 305-317

Traditional Knowledge

Mechanism of Action

Repairing damaged neurons: Bacosides are reported to promote nerve impulse transmission by repairing damaged neurons. This is done by enhancing kinase activity, neuronal synthesis and restoration of synaptic activity. (Singh HK et. al (1997). Indian J. Pharmacol., 29:5359-365)

B. monniera suppresses the function of AChE in the cerebral cortex, particularly in the parietal cortex and hippocampus, leading to increased availability of Acetylcholine. This facilitates enhanced attention, memory and cognitive processing thereby resulting in enhanced working memory.

Preclinical study

The oral dose (100 mg/kg body weight) of B. monniera extract inhibited acetylcholinesterase differentially in various parts of the animal brain viz. Cerebral cortex (51.6%) > Cerebellum (51%) > Pons (44%) > Thalamus (41.6%) > Hippocampus (38.1%) > Brain stem (34.3%) > Striatum (24.9%).

Clinical studies

In a randomized double-blind placebo-controlled study, 60 healthy elderly volunteers (mean age 62) consisting of 23 males and 37 females, received either a standardized extract of B. monniera (300 and 600 mg) or placebo daily for 12 weeks.

B. monniera at a dose of 300mg/day was found to

- Improve memory power

- Improve speed & continuity of attention

- Improve memory quality

- Decrease age related negative deflection (N100) and positive deflection (P300) latencies.

=P <0.05, *=P < 0.01, *** = P < 0.001 when compared to placebo-treated group.

B. monniera extract (300mg/kg) suppresses AChE activity resulting in enhanced cholinergic function, which in turn enhances attention and memory processing and gives rise to increased working memory.

These results suggest that B. monniera can improve attention, cognitive processing, and working memory partly via the suppression of AChE activity.

Nutraceutical Applications:

✔ Supports Normal Memory Function and Reduces Absent mindedness*

✔ Improves Mild Memory Problems Associated With Aging*

✔ Promotes Brain Function And Mental Clarity*

✔ Reduces Stress-Related Anxiety *

✔ Improves Memory, Focus And Recall In Healthy People*

Dosage form and Suggested use level:

Bacopin® can be used in the form of capsules or tablets.

Suggested use level of Bacopin® 50%

Adult : 50 mg of extract 3 times daily.

Children : 25 mg of extract 3 times daily.

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